Stochastic Analysis of Toggle Switch and Toxin-Antitoxin Modules

08/26/2009 13:30
08/26/2009 14:30
America/New York
Ofer Biham, Professor of Physics at the Racah Institute of Physics at the Hebrew University of Jerusalem, Israel will present a seminar at MSSM on August 26, 2009 at 1:30 PM. Click here for Biham website
Location: Annenberg 20-01
Title: Stochastic analysis of toggle switch and toxin-antitoxin modules
Abstract:

Regulation processes in cells are performed by networks of interacting genes, which regulate each other's expression. To analyze the function of genetic networks, we simulate the dynamics of small functional modules using stochastic methods which take into account the effects of fluctuations.

In this talk I will consider two genetic modules - the toggle switch (encoded synthetically on plasmids) and the toxin-antitoxin system (I will focus on the hipBA module in E. coli). I will show that in such modules, which include feedback, fluctuations give rise to crucial quantitative and qualitative effects. For the toggle switch I will show how the details of the system architecture affect the bistable state and the switching time. For the hipBA toxin-antitoxin system, I will focus on its role in the phenomenon of bacterial persistence.


Seminar registration: The lecture is free and open to all. People who wish to participate should RSVP to Uri Hershberg (uri.hershberg@yale.edu) or Hanna Pincas (hanna.pincas@mssm.edu)